Mark your calendars, 49ers fans—the 2026 NFL schedule is finally here! The league's official schedule release week kicks off with a bang, and the San Francisco 49ers' full week-by-week lineup, alongside every other team, will be unveiled on Thursday, May 14, at 8:35 p.m. ET. Some primetime and holiday matchups have already leaked, giving us a tantalizing preview of what's to come.

The action starts early for the Niners, with a Week 1 showdown against the division rival Los Angeles Rams on September 10. That's a must-watch opener that sets the tone for the season. Beyond that, the schedule is packed with highlights: a trip to Mexico City in Week 11 to face the Minnesota Vikings on November 22 adds an international flair, while other weeks remain to be filled in—stay tuned as the full slate drops.

Whether you're gearing up for game day or just planning your season, this is the year to rep your team in style. Get ready for a thrilling ride through the 2026 campaign!