Inter Milan's preparations for Friday's Serie A clash against Cagliari have been dealt a significant blow, with two key defenders ruled out of the home fixture. Captain and talisman Lautaro Martínez, the league's top scorer, will be unavailable due to suspension after accumulating yellow cards. He will be joined on the sidelines by German center-back Yann Bisseck, who is sidelined with a thigh strain.

Martínez's absence robs the Nerazzurri of their primary attacking threat, leaving a major void to fill against a Cagliari side battling relegation. The Argentine's leadership and goal-scoring prowess will be sorely missed as Inter looks to maintain their commanding position at the top of the table.

Bisseck's injury further complicates matters for manager Simone Inzaghi, thinning the defensive options. The young defender had been growing into a reliable role this season, and his physical presence will be a loss against a physical Cagliari attack.

This double setback forces a tactical reshuffle for the league leaders. All eyes will now be on which players step up to fill the gaps, testing the squad's depth as they aim for another crucial three points in their Scudetto pursuit.