The countdown to the NFL schedule release is on, and there's already a marquee matchup on the horizon: the Los Angeles Rams will face the San Francisco 49ers in Week 1, and they're doing it on an international stage in Melbourne, Australia.

While the Rams used their 13th overall pick in the draft on Simpson—a player with long-term potential rather than immediate impact—the betting lines show confidence in L.A. right now. The Rams are currently favored by 2.5 points over their NFC West rivals, signaling that oddsmakers and league observers still hold this team in high regard heading into the 2026 season.

Of course, a lot can change between now and kickoff. Injuries, free-agent signings, and trades can shift the landscape in an instant. If you're keeping an eye on the lines, it pays to stay updated as we move closer to Week 1. After the first full week of NFL action, there will be plenty of new data to analyze, but for now, the focus is squarely on this opening clash.

In a 17-game season, every single contest matters. Whoever emerges victorious in Melbourne will gain an early edge in the playoff race—and a head start over a division rival. The Rams are looking to start their campaign with a statement win, but you can bet the 49ers have their own plans to spoil the party.