The NFL has officially set the date for its 2026 schedule release, with all 272 regular-season games dropping on Thursday, May 14. While a handful of matchups have already leaked through international game announcements and season openers, a select few stand head and shoulders above the rest. From bitter divisional rematches to high-stakes grudge games, here are the seven most anticipated matchups you won't want to miss.
Rams vs. Seahawks
The Rams and Seahawks delivered one of the most thrilling playoff games of the 2025 season, and this rivalry is only heating up. Seattle not only outdueled Los Angeles in the NFC Championship Game but also sparked controversy during its division-winning run. In a wild Thursday Night Football clash, the Seahawks converted a game-changing two-point attempt in unconventional fashion—forcing overtime, stealing the win, and snatching the division crown. Can the Rams finally break their losing streak in Seattle?
Bears vs. Packers
Quarterback Caleb Williams earned the "Ice Man" nickname in dramatic style after Chicago toppled Green Bay in back-to-back games for the first time in years. Bears fans haven't let the Packers forget it, and Williams has even moved to trademark both the nickname and the silhouette from his iconic fourth-down conversion. Can Green Bay reclaim control of this storied rivalry, or did the Bears permanently shift the balance in their Wild Card thriller?
Patriots vs. Seahawks
The challenge won't get any easier for New England, which must travel to one of the league's toughest road environments. The Patriots revamped their offensive line over the offseason, but the sting of their Super Bowl LX loss still lingers. Can they get revenge on the road? Bonus question: Should the NFL make this the regular-season opener?
Falcons vs. Buccaneers
This matchup might be the offseason's most underrated storyline. Kevin Stefanski left the Cleveland Browns and now joins division rival Atlanta, setting up a reunion with former quarterback Baker Mayfield. Mayfield has made it clear there's no love lost—he even took a shot at Stefanski after an Atlanta reporter labeled him a failure during his time in Cleveland. Nothing fuels a rivalry quite like bad blood, and this one is ready to ignite.
Whether you're a die-hard fan or just love a good storyline, these games promise fireworks. Mark your calendars for May 14 and get ready to plan your season—and your game-day gear.