Game 5 of the Cavaliers vs. Pistons series is set for an 8 p.m. ET tip-off, and all eyes are on Cleveland guard Donovan Mitchell. After erupting for 43 points in Monday's win—including a staggering 39 in the second half—Mitchell remains the centerpiece for Wednesday's NBA prop bets. While his scoring was off the charts, he managed just two assists that night. His over/under for total assists tonight is set at 3.5, but don't let that low number fool you. Mitchell averaged 5.7 assists per game during the regular season, and the SportsLine Projection Model expects him to bounce back, projecting 4.6 assists on average.

On the other side, SportsLine NBA expert Alex Selesnick is fading Pistons forward Tobias Harris in Game 5. Harris has been a steady contributor in this series, averaging 19.5 points and 7.0 rebounds per game. His combined points + assists + rebounds over/under is 27.5. "We've unsuccessfully faded Harris twice in this series, but I am not afraid to go right back to the proverbial well again," Selesnick said. While Harris has been a reliable secondary scorer, these numbers may not hold up against a Cavaliers defense finding its rhythm at home.

For those placing bets on FanDuel or other sportsbooks, the SportsLine Projection Model offers a data-driven edge. Simulating every NBA game 10,000 times, the model has returned over $10,000 in betting profit for $100 players on its top-rated picks over the past eight-plus seasons. Entering the second week of the second round of the 2026 NBA playoffs, it's on a hot 26-9 run (74%) on top-rated spread picks this season. Whether you're a seasoned bettor or just looking for an edge, these prop picks could be your ticket to a winning night.