It's a jam-packed Saturday of Major League Baseball, with 15 games on the docket for May 16, and the league's top power hitters are ready to put on a show. For fans looking to add some extra excitement to their game-day experience, home run prop bets offer a thrilling way to engage with every at-bat. After breaking down the full slate of matchups and starting pitchers, we've zeroed in on two National League sluggers who are off to blistering starts in 2026. These are our top picks to go yard today.

First up is Kyle Schwarber, who is doing what he does best: hitting dingers with remarkable consistency. The 2025 NL MVP runner-up is on a tear, leading all of baseball with 20 home runs this season after swatting 56 last year. He enters the weekend having homered three times in his last two games alone. The matchup is highly favorable: Schwarber will face Pittsburgh Pirates right-hander Bubba Chandler, who has surrendered four home runs over his last four starts and six in his last six outings. Notably, four of those homers have come off the bats of left-handed hitters—a promising sign for Schwarber, who has crushed 14 of his 20 homers against right-handed pitching this season.

Our second pick is Ildemaro Vargas, one of the more surprising success stories of the 2026 season. The 34-year-old switch-hitter is batting .347 in his 10th MLB campaign, finally establishing himself as an everyday player and a lineup cornerstone. Vargas has already set a career high with seven home runs, showcasing a well-rounded approach at the plate. While he generates more power from the right side, he still boasts an impressive .871 OPS against right-handed pitchers. On Saturday, he faces Colorado Rockies righty Tomoyuki Sugano at Coors Field, the most hitter-friendly ballpark in the majors. With Sugano struggling to keep the ball in the yard, Vargas is primed to add to his home run total in a prime spot.