Wednesday's packed 15-game MLB slate offers a prime opportunity for prop bettors, and SportsLine expert Jacob Fetner has identified his top home run picks. Fetner, who finished last season up an impressive 50 units on his home run selections, is already up 5.6 units this week. His hot streak includes successfully backing Pirates second baseman Brandon Lowe to homer in both Monday's and Tuesday's wins over the Nationals.

Fetner is going back to the well with Lowe for Wednesday's matchup. "We are going back to the well again with Lowe, who has cashed HR props each of the last two days for us," Fetner noted. "He's now hit four home runs over his last three games." The lefty slugger has a strong track record against right-handed pitching, boasting a .286 average and .921 OPS against them over the past year, with 32 of his 38 homers coming off righties. With the Pirates favored at home against the Nationals, Fetner sees strong value in Lowe's current odds.

His second key pick is the Angels' Mickey Moniak. The outfielder has shown immense power to start the season, with five of his nine hits leaving the yard. He faces Astros rookie Spencer Arrighetti, who is making his first start of 2024 after struggling in the majors last season. Moniak, like Lowe, feasts on right-handed pitching (.277 average, .870 OPS last year), and the hitter-friendly park conditions for today's game only add to his appeal for a deep shot.

For a true longshot with high-reward potential, Fetner points to Blue Jays' Spencer Horwitz. He's taking a shot against Nationals starter Jake Irvin, who has allowed the most home runs in the majors since the start of last season. Horwitz has shown capable pop against right-handers, making the plus-money odds an intriguing gamble for Wednesday's action.