The Cubs (17-11) 10-game winning streak was snapped against the Dodgers and after coming off two straight losses, Chicago heads to San Diego (18-9) for a three-game series versus the Padres.
San Diego is 13-3 over the last 16 games and 5-3 in the past eight as the heaters started to cool down. The Padres lost its last game, 12-7, versus the Diamondbacks. San Diego has scored 23 runs in the last three games, but surrendered 24.
Chicago lost its last two games, 12-4 and 6-0, which came after scoring five or more runs in five straight. The Cubs have the second-most walks (26), batting .305 (3rd), and have 12 home runs (tied 3rd) over the last seven days (six games).
Let’s dive into the matchup and find a sweat or two.
We’ve got all the info and analysis you need to know ahead of the game, including the latest info on the how to catch first pitch, odds, recent team performance, player stats, and of course, our predictions, picks & best bets for the game from our modeling tools and staff of experts.
Follow Rotoworld Player News for the latest fantasy and betting player news and analysis all season long.
Never miss a second of the action and stay up-to-date with all the latest team stats and player news. Check out our day-by-day MLB schedule page, along with detailed matchup pages that update live in-game with every out.
Moneyline: San Diego Padres (-115), Chicago Cubs (-105)
Monday's pitching matchup (April 27): Randy Vasquez vs. Matthew Boyd
2026 stats: 28.2 IP, 2-0, 1.88 ERA, 1.08 WHIP, 30 Ks, 8 BB
2026 Stats: 14.0 IP, 1-1, 5.79 ERA, 1.14 WHIP, 22 Ks, 3 BB
The Cubs’ Moises Ballesteros is hitting .397 with 23 hits and 40 total bases over 58 at-bats
The Cubs’ Michael Busch is hitting .214 with 22 hits and 25 strikeouts over 103 at-bats
The Padres’ Xander Bogaerts is hitting .278 with 27 hits and 41 total bases over 97 at-bats
The Padres’ Jake Croneworth is hitting .155 with 13 hits and 20 strikeouts over 84 at-bats
Rotoworld still has you covered with all the latest MLB player news for all 30 teams. Check out the feed page right here on NBC Sports for headlines, injuries and transactions where you can filter by league, team, positions and news type!
Top betting trends & insights to know ahead of Cubs at Padres
The Padres are 17-10 ATS this season, ranking fourth-best
The Cubs are 17-10-1 to the Over this season, ranking sixth-best
The Padres are 15-11-1 to the Under this season, ranking second-best