The Buffalo Bills are about to make history—and they're doing it under the bright lights of Thursday Night Football. The NFL has confirmed that Buffalo will officially open their brand-new stadium in Week 2, hosting the Detroit Lions on September 17. It's a moment fans have been waiting for, and the stage couldn't be bigger.

This game marks the first ever played at Highmark Stadium, the Bills' state-of-the-art $2 billion facility located just across Abbott Road from their longtime home. That old venue, which opened as Rich Stadium in 1973, has seen decades of snowy Sundays and playoff magic—but now it's time for a new chapter. Prime Video will broadcast the matchup as part of its Thursday Night Football package, giving the whole country a front-row seat to the unveiling.

The Lions won't be an easy opponent, but Buffalo has plenty of momentum on their side. The Bills have won their last four home openers dating back to 2022, averaging a staggering 38.5 points per game in those contests. If that trend continues, fans at the new stadium are in for a treat.

With the full NFL schedule set to drop this Thursday, anticipation is building across the league. But for now, all eyes are on Buffalo—and a September night that promises to be unforgettable.