The 2026 NBA playoffs are heating up, and Wednesday night brings two must-watch Game 2 matchups that could swing the momentum in each conference. For fans and bettors alike, this is the perfect time to look for an edge—and according to SportsLine's powerful computer model, there's a three-way parlay that could return nearly +600.

First up, the New York Knicks host the Philadelphia 76ers at 7 p.m. ET, with the Knicks favored by 7.5 points. Later, the San Antonio Spurs take on the Minnesota Timberwolves at 9:30 p.m. ET, where the Spurs are 9.5-point favorites. Both games have a total set at 215.5, setting the stage for a night of high-stakes basketball.

The model, which simulates every NBA game 10,000 times, has been on fire this season. It's racked up over $10,000 in betting profit for $100 players on its top-rated picks over the past eight-plus seasons. Entering the second round, it's an impressive 26-9 (74%) on spread picks alone. That kind of consistency is hard to ignore, especially when you're looking for a reliable parlay.

One of the model's strongest plays? The Knicks to cover the -7.5 spread against the 76ers. While Philadelphia fought hard as the seventh seed, their road record sits at 25-21, and they averaged 115.9 points per game during the regular season—good but not great. The Knicks, meanwhile, boast a top-10 offense at 116.5 points per game, led by Jalen Brunson, who the model projects to drop 28.2 points. In fact, the model forecasts New York to win by 13 points, making this an A-rated pick that hits in 67% of simulations.

For the 76ers, Tyrese Maxey is expected to lead with 25.4 points, but it may not be enough against a deep Knicks roster that has five players projected to score 11.8 points or more. This is the kind of matchup where depth and home-court advantage shine.

Whether you're a die-hard fan or just looking to add some excitement to the game, these picks offer a data-driven path to a big payout. Pair them with the model's other confident selections, and you could be looking at a nearly +600 return on your parlay. It's the kind of edge that makes playoff basketball even more thrilling.